Perimenopause & women’s health

Clinical insights from a Registered Nurse. Written for women who want real answers, not generic advice.

Complex Conditions

GLP-1 medicines and MCAS: what we know and what we don't

Could the medicines many women now take for weight and blood sugar calm mast cells too? A Registered Nurse looks at the early reports, the side effects and the open questions.

Anna-Klara Skarp, RN  ·  6 October 2026  ·  8 min read
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Hormones & Complex Conditions

Progesterone and MCAS: calming for some, a trigger for others

Progesterone often calms mast cells, yet some women react to it. A Registered Nurse explains progestogen hypersensitivity, cycle-linked flares and why perimenopause can bring them to the surface.

Anna-Klara Skarp, RN  ·  6 October 2026  ·  7 min read
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Complex Conditions

Seven years to be believed: what Australia's POTS research is telling women

For Dysautonomia Awareness Month: five findings from Australia's national POTS registry, from diagnostic delay for women to brain fog and post-viral POTS.

Anna-Klara Skarp, RN  ·  6 October 2026  ·  7 min read
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Hormones & Complex Conditions

Your gut and your hormones: the estrobolome, explained simply

Your gut bacteria help control how much oestrogen recirculates in your body. A Registered Nurse explains the estrobolome in plain language, and why gut, hormone and histamine symptoms cluster together in perimenopause.

Anna-Klara Skarp, RN  ·  18 September 2026  ·  8 min read
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Bone Health & Menopause

Joint pain in perimenopause: the musculoskeletal syndrome of menopause

Achy knees, new stiffness or a frozen shoulder in your 40s? A Registered Nurse explains why falling oestrogen affects your joints and tendons, and what genuinely helps.

Anna-Klara Skarp, RN  ·  7 September 2026  ·  8 min read
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Histamine & Hormones

The low-histamine starter guide: what the evidence actually supports

Ready to move past what histamine intolerance is and into what to actually do. A Registered Nurse explains the elimination-reintroduction process, what DAO supplements can and cannot do, and why the least restriction that works beats a lifetime of blanket avoidance.

Anna-Klara Skarp, RN  ·  31 August 2026  ·  7 min read
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Hormones & Complex Conditions

Heart palpitations in perimenopause: hormones, histamine or something else?

A racing or pounding heart is one of the most unsettling perimenopause symptoms. A Registered Nurse explains what’s common, what needs a GP visit first, and how hormones, POTS, histamine and anxiety can each play a part.

Anna-Klara Skarp, RN  ·  24 August 2026  ·  7 min read
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Perimenopause & Mental Health

Perimenopause and ADHD: why symptoms surface or intensify in midlife

Losing words mid-sentence, missing appointments, feeling scattered in ways you never used to. A Registered Nurse explains the oestrogen-dopamine link and why so many women are diagnosed with ADHD in perimenopause.

Anna-Klara Skarp, RN  ·  17 August 2026  ·  8 min read
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Complex Conditions

Dysautonomia in perimenopause: when your body's autopilot stops cooperating

Dizzy on standing, a racing heart, gut trouble, temperature swings. A Registered Nurse explains dysautonomia, why perimenopause destabilises the autonomic nervous system, and what helps.

Anna-Klara Skarp, RN  ·  12 August 2026  ·  8 min read
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Hormones & Complex Conditions

Can you take HRT if you have MCAS? What the evidence says

Worried HRT will trigger your Mast Cell Activation Syndrome, or already reacting to it? A Registered Nurse breaks down what the evidence says about oestrogen, progesterone and mast cells, and why dose and route matter.

Anna-Klara Skarp, RN  ·  19 July 2026  ·  7 min read
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Complex Conditions & POTS

Heart racing when you stand? POTS, MCAS and histamine in perimenopause

Dizzy on standing, random flushing, sudden reactions to food you used to eat easily. A Registered Nurse explains POTS, MCAS and why histamine is central to both, and why so many women are told it is just anxiety.

Anna-Klara Skarp, RN  ·  11 July 2026  ·  9 min read
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Exercise & Strength Training

Weight training in perimenopause: why it comes first and how much you actually need

Not all exercise is equal in perimenopause. What the research says about strength training, HIIT, cardio, and the minimum and optimal dose of each.

Anna-Klara Skarp, RN  ·  10 July 2026  ·  14 min read
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Sleep, Weight & Hormones

Sleep, cortisol and appetite in midlife: the four systems behind menopause weight change

The 3am wake-up and the afternoon sugar craving are the same problem. A Registered Nurse explains the four interconnected hormonal systems behind midlife weight change.

Anna-Klara Skarp, RN  ·  10 July 2026  ·  10 min read
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Bone Health & Menopause

Protecting your bones through perimenopause and beyond

Bone health rarely makes it into the perimenopause conversation until something breaks. Here’s why your 40s and 50s are the years that matter most, and what genuinely helps.

Anna-Klara Skarp, RN  ·  20 June 2026  ·  12 min read
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Perimenopause & Weight

Why won’t my weight shift in perimenopause?

Eating well and exercising but still gaining weight? Here’s what’s actually happening hormonally and what the evidence says actually helps.

Anna-Klara Skarp, RN  ·  17 May 2026
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Perimenopause & Mental Health

Is it perimenopause or anxiety? How to tell the difference

Feeling anxious in ways that don’t feel like you? A Registered Nurse explains why perimenopause is so often misdiagnosed as anxiety, and what the real drivers are.

Anna-Klara Skarp, RN  ·  17 May 2026
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Histamine & Hormones

What is histamine intolerance and why is it so common in perimenopause?

Unexplained bloating, flushing, headaches, or palpitations? The oestrogen-histamine connection may explain symptoms that have puzzled you for years.

Anna-Klara Skarp, RN  ·  17 May 2026
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All articles are written by Anna-Klara Skarp, Registered Nurse (AHPRA NMW0002238991) and HCANZA Certified Health Coach.
Content is evidence-based and for informational purposes. It does not constitute medical advice. If you have health concerns, please consult a qualified healthcare practitioner.